Arabino-mycolates derived from cell-wall skeleton of Mycobacterium bovis BCG as a prominent structure for recognition by host immunity.

Incorporation of Radiolabelled Substrates into Mycobacteri- al Lipids of M. Bovis BCG and M. Kansasii

Background: Diseases caused by microorganisms of the genus Mycobacterium continue to be a serious problem. The cell envelope constitutes up to 60% of the dry weight of lipids. The cell wall of the mycobacterium is essential for their growth and survival in the infected host. The cell wall lipids have been isolated from M. bovis BCG and M. kansasii mycobacterial strains and studied the incorpora...

Toll-like receptor signaling in anti-cancer immunity.

It is important to augment the anti-cancer host response in cancer treatment. Recent studies suggested that the signaling via Toll-like receptors (TLRs) which are newly identified receptor molecules recognizing many pathogens, are involved in the induction of anti-cancer immunity. Seya et al. demonstrated that maturation of dendritic cells (DCs) and cytokine induction by the cell wall skeleton ...

Trehalose Mycolates Calmette-Guérin Is Due Principally to Bacillus Mycobacterium bovis of In Vivo Activity of Released Cell Wall Lipids

M.tuberculosis Mutants Lacking Oxygenated Mycolates Show Increased Immunogenicity and Protective Efficacy as Compared to M. bovis BCG Vaccine in an Experimental Mouse Model

The existing vaccine against tuberculosis (M. bovis BCG) exerts some protection against the extrapulmonary forms of the disease, particularly in young children, but is not very effective against the pulmonary form of TB, which often results from the reactivation of a latent M. tuberculosis (M.tb)infection. Among the new approaches in TB vaccine development, live attenuated M.tb mutants are a pr...

Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.

We have analyzed the gene expression profile of monocytes in response to a highly purified cell wall fraction of Mycobacterium bovis BCG, a clinically approved adjuvant known as BCG cell wall skeleton (BCG-CWS). It is composed of mycolic acid, arabinogalactan, and peptidoglycan and confers Toll-like receptor 2 (TLR2)- and TLR4-dependent signaling that induces monocytes to differentiate into ant...